Cumyl-PEGACLONE initially appeared on the market in the form of herbal blends and e-liquids and became available as a pure ‘research chemical’ in July 2017. 6 Since then, several research groups have characterized this new compound, its metabolization and, to a lesser extent, its cannabinoid activity. The psychoactive effects, most desired by (ab)users, but also several adverse effects, mainly stem from CB 1 receptor activation. …
… Not surprisingly, identification and case reports for both Cumyl-PEGACLONE and 5F-Cumyl-PEGACLONE have emerged since then. 6,Initially, SCRAs containing a γ-carbolinone core structure were hypothesized to be relatively safe, as no lethalities were observed in cases with (over)consumption of Cumyl-PEGACLONE. However, several fatalities have been reported during the past few years. …
… 10,13 Therefore, the relative ‘safety’ of γ-carbolinones can be questioned. 6,10,13 As fluorination can have a beneficial effect on a compound’s activity, resulting in a higher potency, it could be hypothesized that this would lead to a higher toxicity of 5F-Cumyl-PEGACLONE. 7,14,15 However, no activity data are available to confirm this hypothesis. …

Particularly, 5-pentyl-2-(2-phenylpropan-2-yl)-2,5-dihydro-1H-pyrido [4,3-b]indol-1-one (semisystematic name: Cumyl-PEGACLONE or SGT-151) was the first SC with a γ-carbolinone core structure detected in forensic casework and, since then, it has dominated the German SC-market . It has indeed been detected in about 25% of herbal blends purchased in Germany during a monitoring program and has showed high prevalence in biological specimens . …Buy CHM-SGT-151 CUMYL-PEGACLONE (SGT-151)
… Particularly, 5-pentyl-2-(2-phenylpropan-2-yl)-2,5-dihydro-1H-pyrido [4,3-b]indol-1-one (semisystematic name: Cumyl-PEGACLONE or SGT-151) was the first SC with a γ-carbolinone core structure detected in forensic casework and, since then, it has dominated the German SC-market [. It has indeed been detected in about 25% of herbal blends purchased in Germany during a monitoring program and has showed high prevalence in biological specimens . …Buy CHM-SGT-151 CUMYL-PEGACLONE (SGT-151)
… High, NPS likely to have contributed to toxicity/death, despite the detection of other drugs) is assigned . Six cases of death related to the intake of Cumyl-PEGACLONE were reported, in none of which, according to the TSS, the substance seemed to have played a causative role . Due to the relatively low occurrence of severe intoxications and of deaths caused by Cumyl-PEGACLONE, the compound has been suggested as a “comparatively safe drug” and a relative “low toxicity” of SCs bearing a γ-carbolinone core structure was considered possible . …Buy CHM-SGT-151 CUMYL-PEGACLONE (SGT-151)

. In-vivo-Metabolismus von 5F-Cumyl-PEGACLONE die 5-Fluorpentyl-Seitenkette und die γ-Carbolinon-Kernstruktur bevorzugt metabolisiert. Im Gegensatz zum Indol-Analogon 5F-Cumyl-PICA und dem Indazol-Analogon 5F-Cumyl-PINACA und Japan bisher nicht aufgetreten ist . …Buy CHM-SGT-151 CUMYL-PEGACLONE (SGT-151)
… Kapitel 3.3), wurden für Cumyl-PEGACLONE bisher nur wenige Vergiftungsfälle und keine Todesfälle beschrieben. Daher wurde diskutiert, ob es sich bei Cumyl-PEGACLONE um ein SC mit vergleichsweise niedriger Toxizität handelt . Konsummarker-Metaboliten sind dem Anhang A-2 zu entnehmen). …
… So zeigte sich in dieser Arbeit am Beispiel von Cumyl-PEGACLONE und 5F-Cumyl-PEGACLONE, dass ein als relativ untoxisch eingestuftes SC nach dessen Abbildung Anhang 3 Definition der Seitenkette nach NpSG in der Piktogramm Darstellung. Unter a) Beispiele typischer substituierter Seitenketten; b) Beispiele typischer Ringsysteme als Seitenketten. …Buy CHM-SGT-151 CUMYL-PEGACLONE (SGT-151)